I've been playing this recently. The controls do take some getting used to, and can get uncomfortable - especially if you have big hands like I have. Otherwise, it's really fun, and the dialogue is absolutely hilarious.
I put it aside for a while but I've picked it up again recently. I've taken to using the stand that came with the game and the controls are much more bearable now. I can play it without it, but it gets uncomfortable after a while. Again, it's an absolutely hilarious game, and the amount of customization in weapons and abilities is really daunting. It's also got a lot of replayability with the intensity settings. I've heard it's a lot better on the 3DS XL, especially for people with big hands, but I just can't justify buying one when my 3DS works perfectly.